Propanal → 1-(2,3,5-Trimethyl-6-pyrazinyl)-1-propanone

HRID 280365

반응식

[CH3:1][C:2]1[N:3]=[C:4]([CH3:9])[C:5]([CH3:8])=[N:6]C=1.[CH:10](=O)CC.[CH3:14][C:15]([CH3:17])=[O:16].CCCCCC>>[CH3:8][C:5]1[C:4]([CH3:9])=[N:3][C:2]([CH3:1])=[C:14]([C:15](=[O:16])[CH2:17][CH3:10])[N:6]=1

참가 물질

반응물 3

HCID 527Propanal

HCID 26808Trimethylpyrazine

HCID 21880519Acetone hexane

생성물 1

HCID 5779401-(2,3,5-Trimethyl-6-pyrazinyl)-1-propanone수율 48%

실험 절차

The reaction of trimethylpyrazine and freshly distilled propionaldehyde is carried out as described in Example I on the same molar scale. Preparative thick layer chromatography (2000μ silica gel GF, developed in 5% acetone/hexane) of the crude reaction product gives a 48% yield of 1-(2,3,5-trimethyl-6-pyrazinyl)-1-propanone (mp 65°-67° C.).

출처 및 근거

ORD 기록: ord-710dd3b964a44ac399f8e14a0cefb831
출처 데이터셋: uspto-grants-1986_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04588813

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