Aluminum isopropoxide → Thiazole, 5-(methoxymethyl)-4-methyl-

HRID 2804노트

반응식

HRID 2804 반응식
[CH3:1][C:2]1[N:3]=[CH:4][S:5][C:6]=1[CH:7]=[O:8].[CH3:9]C(C)[O-].[Al+3].CC(C)[O-].CC(C)[O-].[H-].[Na+]>CC(O)C.C(COC)OC.IC>[CH3:9][O:8][CH2:7][C:6]1[S:5][CH:4]=[N:3][C:2]=1[CH3:1]

참가 물질

7

반응물 3

HCID 11143Aluminum isopropoxideHCID 24758Sodium hydrideHCID 5813394-Methylthiazole-5-carboxaldehyde

생성물 1

HCID 11571819Thiazole, 5-(methoxymethyl)-4-methyl-

시약·촉매·용매 3

HCID 3776Isopropanol용매HCID 6328Methyl iodide용매HCID 80711,2-Dimethoxyethane용매

실험 절차

4-Methyl-5-thiazolecarbaldehyde (J. Amer. Chem. Soc., 1982, 104, 4934-4943) was reduced using aluminium isopropoxide in 2-propanol. The resulting alcohol was treated with sodium hydride in dimethoxyethane and iodomethane was added. Distillation gave the title compound.

후처리

  1. additionwas added
  2. distillationDistillation

출처 및 근거

ORD 기록
ord-7f93372015354dc38e885820152952ed
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731335

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