Formaldehyde → 7-Bromo-2-dimethylaminomethyl-1-tetralone hydrochloride

HRID 280627노트

반응식

HRID 280627 반응식
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH2:8][C:9]2=[O:12])=[CH:4][CH:3]=1.[ClH:13].[CH3:14][NH:15][CH3:16].[CH2:17]=O>Cl.C(O)C>[ClH:13].[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][CH:8]([CH2:14][N:15]([CH3:17])[CH3:16])[C:9]2=[O:12])=[CH:4][CH:3]=1

참가 물질

6

반응물 3

HCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 2527317-Bromo-1,2,3,4-tetrahydronaphthalen-1-one

생성물 1

HCID 233209337-Bromo-2-dimethylaminomethyl-1-tetralone hydrochloride

시약·촉매·용매 2

HCID 313Hydrochloric Acid촉매HCID 702Ethanol용매

실험 절차

A mixture of 7-bromo-1-tetralone (4.50 g), dimethylamine hydrochloride (2.50 g), paraformaldehyde (1.0 g), ethanol (6 ml) and concentrated hydrochloric acid (4 drops) was heated under reflux for two hours and cooled. The mixture was diluted with a few ml. of acetone and the solid was filtered off, washed with a little acetone and dried to give 7-bromo-2-dimethylaminomethyl-1-tetralone hydrochloride, m.p. 169°-171°, pure enough for further reaction.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for two hours
  3. temperaturecooled
  4. additionThe mixture was diluted with a few ml
  5. filtrationof acetone and the solid was filtered off
  6. washwashed with a little acetone
  7. customdried

출처 및 근거

ORD 기록
ord-d3d0fbaff7b24b45bce90989ea617b9a
출처 데이터셋
uspto-grants-1986_05
특허 번호
US04590200

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