2,4-Dichlorobenzyl chloride → 2,4-Dichlorobenzylthio-acetic acid

HRID 28181

반응식

HRID 28181 반응식
NC(N)=[S:3].[Cl:5][C:6]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:7]=1[CH2:8]Cl.[OH-].[Na+].Cl[CH2:18][C:19]([O-:21])=O.[Na+]>O>[Cl:5][C:6]1[CH:13]=[C:12]([Cl:14])[CH:11]=[CH:10][C:7]=1[CH2:8][CH2:18][C:19]([OH:21])=[S:3]

참가 물질

6

반응물 4

HCID 72122,4-Dichlorobenzyl chlorideHCID 14798Sodium HydroxideHCID 2723790ThioureaHCID 23665759Sodium chloroacetate

생성물 1

HCID 1785261732,4-Dichlorobenzylthio-acetic acid수율 88.7%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

15.2 g (0.2 mol) of thiourea in 100 ml of water are introduced into a 1 liter 3-necked flask. The mixture is heated to 50°-60° C. and 39.1 g (0.2 mol) of 2,4-dichlorobenzylchloride are introduced in a single operation. The mixture is heated under reflux and boiling is maintained for 15 minutes; the solution becomes limpid. The mixture is cooled and a solution of 32 g (0.8 mol) of NaOH in 50 ml of water is introduced dropwise at about 60° C. The mixture is again heated under reflux for 30 minutes, cooled and a solution of about 0.28 mol of sodium chloroacetate (obtained by neutralising 26.46 g of chloroacetic acid in 200 ml of water with 23.52 g of NaHCO3) is introduced, dropwise, at 60°-70° C. The whole is then heated under reflux for 30 minutes, cooled, filtered and acidified with 3 N HCl; the precipitate obtained is filtered off the redissolved cold in dilute sodium bicarbonate solution, and this solution is washed with methylene chloride, filtered and again acidified. 41.7 g (yield: 83 %) of product are thus collected. Instantaneous melting point: 72°-73° C.

후처리

  1. temperatureThe mixture is heated to 50°-60° C.
  2. temperatureThe mixture is heated
  3. temperatureunder reflux
  4. temperatureboiling is maintained for 15 minutes
  5. temperatureThe mixture is cooled
  6. temperatureThe mixture is again heated
  7. temperatureunder reflux for 30 minutes
  8. temperaturecooled
  9. customat 60°-70° C
  10. temperatureThe whole is then heated
  11. temperatureunder reflux for 30 minutes
  12. temperaturecooled
  13. filtrationfiltered
  14. customthe precipitate obtained
  15. filtrationis filtered off the redissolved cold in dilute sodium bicarbonate solution
  16. washthis solution is washed with methylene chloride
  17. filtrationfiltered

출처 및 근거

ORD 기록
ord-abd2d97cd76d49eabf871b9bb464d08c
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04225617

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