Hydroquinone → 4-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol

HRID 28312

반응식

HRID 28312 반응식
Cl[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][O:10]1.[C:15]1([CH:22]=[CH:21][C:19]([OH:20])=[CH:18][CH:17]=1)[OH:16].C(=O)([O-])[O-].[K+].[K+].[I-].[K+]>O.CS(C)=O>[O:10]1[CH2:11][CH2:12][CH2:13][CH2:14][CH:9]1[O:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2][O:16][C:15]1[CH:22]=[CH:21][C:19]([OH:20])=[CH:18][CH:17]=1

참가 물질

7

반응물 4

HCID 785HydroquinoneHCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 3298032-(6-Chlorohexyloxy)tetrahydro-2H-pyran

생성물 1

HCID 178385764-(6-(2-Tetrahydropyranyl)oxyhexyloxy)phenol수율 82.5%

시약·촉매·용매 2

HCID 679Dimethyl Sulfoxide용매HCID 962Water용매

실험 절차

A mixture of 10 g of 2-(6-chlorohexyloxy)tetrahydropyrane, 25 g of hydroquinone, 31 g of potassiumcarbonate, 0.752 g of potassiumiodide and 250 ml of dimethylsulfoxide was allowed to react for 4 days at 80° C. Subsequently, the reaction mixture was cooled to room temperature and after addition of water extracted with ether. The organic phase was then dried over sodium sulphate, filtered and concentrated to dryness. Chromatography on silica with 10% ethylacetate in toluene gave 11 g of product as a yellowish oil.

후처리

  1. customto react for 4 days at 80° C
  2. extractionextracted with ether
  3. dry with materialThe organic phase was then dried over sodium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-7f83b244a5014c8fbe2f48fda79a83a5
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07419620B2

연결된 노트

불러오는 중…