Pyrrolidine → 1-(1,3-Dioxobutyl)pyrrolidine

HRID 2849

반응식

HRID 2849 반응식
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[O:6]=[C:2]([CH3:1])[CH2:3][C:4]([N:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1)=[O:5]

참가 물질

4

반응물 2

HCID 31268PyrrolidineHCID 87118046Diketene acetone

생성물 1

HCID 1007221-(1,3-Dioxobutyl)pyrrolidine수율 97.9%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

후처리

  1. customas described in preparation 7
  2. customThe solvent was removed in vacuo
  3. customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

출처 및 근거

ORD 기록
ord-fc50405695d1443a80eda06a3dd99d45
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731322

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