Sodium Hydroxide → HCID 178418269, 화합물

HRID 2854

반응식

HRID 2854 반응식
[CH:1]([N:4]([CH:11]([CH3:13])[CH3:12])[C:5](=[O:10])[CH2:6][C:7](=[O:9])[CH3:8])([CH3:3])[CH3:2].[OH-].[Na+].[Cl-].[C:17]1([N+:23]#[N:24])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>O>[CH:11]([N:4]([CH:1]([CH3:2])[CH3:3])[C:5](=[O:10])[C:6](=[N:24][NH:23][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:7](=[O:9])[CH3:8])([CH3:13])[CH3:12]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 60992Benzenediazonium chlorideHCID 123185413-Oxo-N,N-di(propan-2-yl)butanamide

생성물 1

HCID 178418269HCID 178418269, 화합물수율 68.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

7.0 g (0.038 mol) of N,N-diisopropyl-3-oxobutyramide, a solution of 5.3 g (0.133 mol) of NaOH in 58 ml of water and 0.04 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 95:5) obtaining 7.5 g of the title compound which was used as such in the subsequent step. M.p.=143°-145° C.

후처리

  1. customas described in preparation 8
  2. customThe crude reaction mixture
  3. customwas purified by chromatography on silica gel (hexane/Et2O 95:5)

출처 및 근거

ORD 기록
ord-ee71b009ed3f4c28bab5abd1c42abd9d
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731322

연결된 노트

불러오는 중…