Potassium Cyanide → 4-(7-Methoxy-1-naphthyl)butyronitrile

HRID 2888

반응식

HRID 2888 반응식
[C-:1]#[N:2].[K+].S(O[CH2:9][CH2:10][CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH3:23])[CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=O)(=O)C>CS(C)=O>[CH3:23][O:22][C:19]1[CH:20]=[C:21]2[C:16]([CH:15]=[CH:14][CH:13]=[C:12]2[CH2:11][CH2:10][CH2:9][C:1]#[N:2])=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 9032Potassium CyanideHCID 153368673-(7-Methoxy-1-naphthyl)propyl mesylate

생성물 1

HCID 153368684-(7-Methoxy-1-naphthyl)butyronitrile

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.

후처리

  1. temperatureto reflux for 2 h
  2. temperatureto cool
  3. extractionThe resulting mixture is extracted with ether
  4. washThe organic phase is washed with water
  5. dry with materialdried over CaCl2
  6. customevaporated
  7. customThe product obtained
  8. customis recrystallized

출처 및 근거

ORD 기록
ord-ebf01e6b38bc42c089b9940d05b2423f
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731352

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