Potassium Cyanide → 4-(7-Methoxy-1-naphthyl)butyronitrile
반응식
[C-:1]#[N:2].[K+].S(O[CH2:9][CH2:10][CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH3:23])[CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=O)(=O)C>CS(C)=O>[CH3:23][O:22][C:19]1[CH:20]=[C:21]2[C:16]([CH:15]=[CH:14][CH:13]=[C:12]2[CH2:11][CH2:10][CH2:9][C:1]#[N:2])=[CH:17][CH:18]=1참가 물질
4
실험 절차
In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.
후처리
- temperatureto reflux for 2 h
- temperatureto cool
- extractionThe resulting mixture is extracted with ether
- washThe organic phase is washed with water
- dry with materialdried over CaCl2
- customevaporated
- customThe product obtained
- customis recrystallized
출처 및 근거
- ORD 기록
- ord-ebf01e6b38bc42c089b9940d05b2423f
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05731352
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