Sodium Hydroxide → 4-Chloro-3-methoxyaniline

HRID 29508

반응식

HRID 29508 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[O:11][CH3:12].[OH-].[Na+]>CO.Cl>[CH3:12][O:11][C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][C:2]=1[Cl:1])[NH2:8]

참가 물질

5

반응물 2

HCID 14798Sodium HydroxideHCID 705192-Chloro-5-nitroanisole

생성물 1

HCID 131036924-Chloro-3-methoxyaniline

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 887Methanol용매

반응 조건

온도
50 °C

실험 절차

2-Chloro-5-nitro anisole (6.0 g, 0.032 mol) in MeOH (45 ml) was added slowly to stannous chloride (15.1 g, 0.08 mol) in conc. HCl (110 ml) at 40° C. and the temperature was slowly raised to 50° C. Stirring was continued for 2 h. After cooling to RT, the reaction mixture was basified with 50% NaOH solution, extracted by ethyl acetate, washed with water, then brine and dried over Na2SO4. 3-Methoxy-4-chloroaniline was obtained upon concentration and was purified further by column chromatography.

후처리

  1. temperatureAfter cooling to RT
  2. extractionextracted by ethyl acetate
  3. washwashed with water
  4. dry with materialbrine and dried over Na2SO4

출처 및 근거

ORD 기록
ord-e7a1884c2443436e84f576c317dc7d0d
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07420055B2

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