Acetone → 2-(4-Acetamidophenoxy)-2-methylpropanoic acid

HRID 2987

반응식

HRID 2987 반응식
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1.[OH-].[Na+].[C:17](NC1C=CC(O)=CC=1)(=[O:19])[CH3:18].CC(C)=O.C(Cl)(Cl)Cl>>[NH:1]([C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]([CH3:12])([CH3:11])[C:8]([OH:10])=[O:9])=[CH:13][CH:14]=1)[C:17]([CH3:18])=[O:19]

참가 물질

6

반응물 5

HCID 180AcetoneHCID 1983AcetaminophenHCID 6212ChloroformHCID 14798Sodium HydroxideHCID 27749582-(4-Aminophenoxy)-2-methylpropanoic acid

생성물 1

HCID 148798552-(4-Acetamidophenoxy)-2-methylpropanoic acid수율 60%

실험 절차

FIG. 2A illustrates a reaction scheme for preparing 2-(4-aminophenoxy)-2-methyl propionic acid, a compound that is useful as a precursor in the preparation of Group I compounds. In accordance with the scheme of FIG. 2A, 8 grams (g) (0.2 mol) of pulverized sodium hydroxide is added to a suspension of 5.28 g (0.035 mol) of p-acetamidophenol in 23 ml (0.4 mol) of acetone. The reaction mixture is stirred at room temperature for 1/2 hour. Subsequently, 3.58 g (0.03 mol) of chloroform is added dropwise over the course of 30 minutes. The reaction mixture is stirred overnight at room temperature and acetone is removed under vacuum. The residue is dissolved in water (10 ml), followed by acidification with 37% hydrochloric acid (HCl) to produce a pale yellow precipitate of 2-(4-acetaminophenoxy)-2-methyl propionic acid (5 g, 60% yield), crystallized from methanol, mp 69°-71° C.

후처리

  1. customa reaction scheme
  2. customa compound that is useful as a precursor in the preparation of Group I compounds
  3. stirringThe reaction mixture is stirred overnight at room temperature
  4. customacetone is removed under vacuum
  5. dissolutionThe residue is dissolved in water (10 ml)

출처 및 근거

ORD 기록
ord-8d4bf2d31e824543ac5f1049cd6477c4
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05731454

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