Sodium Hydroxide → 1-Chloro-5,7-dimethoxyphthalazine
반응식
[CH3:1][O:2][C:3]1[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=[C:9]2[C:4]=1[CH:5]=[N:6][NH:7][C:8]2=O.P(Cl)(Cl)([Cl:18])=O.[OH-].[Na+]>O>[Cl:18][C:8]1[C:9]2[C:4](=[C:3]([O:2][CH3:1])[CH:12]=[C:11]([O:13][CH3:14])[CH:10]=2)[CH:5]=[N:6][N:7]=1참가 물질
5
실험 절차
1 g (4.9 mmol) of 5,7-dimethoxy-2H-phthalazin-1-one and 10 mL of phosphoryl chloride are heated at 80° C. for 2 hours. After cooling to room temperature, the reaction medium is poured dropwise into 50 mL of water and the mixture is then basified with 6N sodium hydroxide solution and extracted with dichloromethane. The organic phase is washed with water and with brine, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. 1 g of a beige-coloured solid is obtained (91% yield).
후처리
- extractionextracted with dichloromethane
- washThe organic phase is washed with water and with brine
- dry with materialdried over anhydrous sodium sulfate
- customevaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-5c9d0432b10e4a73a778c48ed2ed7938
- 출처 데이터셋
- uspto-grants-2008_09
- 특허 번호
- US07423030B2
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