Sodium Hydroxide → 7-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine
반응식
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[N:8][N:9]=[C:10]2[NH:13][CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=3)[CH2:16][CH2:15]2)=[CH:5][CH:4]=1.Cl.[NH+]1C=CC=CC=1.[OH-].[Na+]>>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[N:8][N:9]=[C:10]2[NH:13][CH:14]2[CH2:15][CH2:16][N:17]([CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=3)[CH2:18][CH2:19]2)=[CH:5][CH:4]=1참가 물질
4
반응 조건
- 온도
- 210 °C
실험 절차
A mixture of 597 mg (1.25 mmol) of 7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine (compound 1) and pyridinium hydrochloride is heated at 210° C. for 45 minutes. The reaction medium is cooled and 1N sodium hydroxide solution is then added. A precipitate forms, which is washed with water and with dichloromethane, and then dried under reduced pressure. 500 mg of a beige-coloured powder are obtained.