Thiophosgene → 4-Methylsulfonylphenylisothiocyanate

HRID 30161

반응식

HRID 30161 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[C:12](Cl)(Cl)=[S:13]>O.Cl>[N:11]([C:8]1[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:6][CH:7]=1)=[C:12]=[S:13]

참가 물질

5

반응물 2

HCID 10040ThiophosgeneHCID 796174-(Methylsulfonyl)aniline

생성물 1

HCID 150782064-Methylsulfonylphenylisothiocyanate수율 85.2%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매HCID 962Water용매

실험 절차

A solution of 4-methanesulfonylphenylamine (2.4 g, 14 mmol) was dissolved in a mixture of water (30 mL) and hydrochloric acid (9 mL, 37%). This was treated drop wise at room temperature with thiophosgene (1.5 g, 13.2 mmol) with good stirring. After 1 h, the suspension was filtered, washed with water and dried over P2O5 to give 2.4 g (85% yield) of 1-isothiocyanato4-methanesulfonylbenzene. 1H NMR (CDCl3), 300 MHz δ3.09 (s, 3H, CH3), 7.41(d, 2H, Aromatic), 7.98 (d, 2H, Aromatic).

후처리

  1. filtrationthe suspension was filtered
  2. washwashed with water
  3. dry with materialdried over P2O5

출처 및 근거

ORD 기록
ord-e092182de60b48639366dedfe02287ff
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07423053B2

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