Diethyl Malonate → HCID 178418389, 화합물
반응식
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[NH:5][C:4]([CH3:10])(N)[N:3]=1.[O-]CC.[Na+].[Na].Cl.C(N)(=N)C.C(OCC)(=O)CC(OCC)=O>C(O)C>[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([CH3:10])[N:3]=1참가 물질
7
실험 절차
The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.
후처리
- temperaturethe reaction mixture heated
출처 및 근거
- ORD 기록
- ord-4d14267579d347aaab5da8765031fa8d
- 출처 데이터셋
- uspto-grants-1998_03
- 특허 번호
- US05732717
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