Diethyl Malonate → HCID 178418389, 화합물

HRID 3046

반응식

HRID 3046 반응식
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[NH:5][C:4]([CH3:10])(N)[N:3]=1.[O-]CC.[Na+].[Na].Cl.C(N)(=N)C.C(OCC)(=O)CC(OCC)=O>C(O)C>[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([CH3:10])[N:3]=1

참가 물질

7

반응물 5

HCID 7761Diethyl MalonateHCID 67170Acetamidine monohydrochlorideHCID 2723922Sodium ethoxideHCID 5360545SodiumHCID 1784183454,6-Dihydroxy-2-methylpyrimidinamine

생성물 1

HCID 178418389HCID 178418389, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.

후처리

  1. temperaturethe reaction mixture heated

출처 및 근거

ORD 기록
ord-4d14267579d347aaab5da8765031fa8d
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05732717

연결된 노트

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