Methyl iodide → HCID 11359854, 화합물

HRID 3058

반응식

HRID 3058 반응식
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1)[NH:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].[C:25](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:23][CH3:25])=[CH:21][CH:22]=1)[NH:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 7010613N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester

생성물 1

HCID 11359854HCID 11359854, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

32.94 g (100 mmol) of N-benzyloxycarbonyl-tyrosine methyl ester is mixed in 200 ml of DMF with 27.64 g (200 mmol) of ground potassium carbonate. 15.6 g (110 mmol) of iodomethane is instilled in this suspension and stirred overnight at room temperature. The solution is concentrated by evaporation, dispersed between ethyl acetate and water, and the organic phase is mixed with hexane after drying (Na2SO4). The title compound crystallizes out.

후처리

  1. concentrationThe solution is concentrated by evaporation
  2. additiondispersed between ethyl acetate and water
  3. additionthe organic phase is mixed with hexane
  4. dry with materialafter drying (Na2SO4)
  5. customThe title compound crystallizes out

출처 및 근거

ORD 기록
ord-dba6f3dde0664944932faac3af102356
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733522

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