Phosphoric Acid → HCID 58972470, 화합물

HRID 30993노트

반응식

HRID 30993 반응식
[CH3:1][O:2][C:3](=[O:29])[CH2:4][N:5]1[C:11](=[O:12])[C@@H:10]([NH:13]C(OC(C)(C)C)=O)[C:9]2[CH:21]=[CH:22][CH:23]=[CH:24][C:8]=2[C:7]2[CH:25]=[CH:26][CH:27]=[CH:28][C:6]1=2.P(=O)(O)(O)O.[OH-].[Na+]>ClCCl>[CH3:1][O:2][C:3](=[O:29])[CH2:4][N:5]1[C:11](=[O:12])[C@@H:10]([NH2:13])[C:9]2[CH:21]=[CH:22][CH:23]=[CH:24][C:8]=2[C:7]2[CH:25]=[CH:26][CH:27]=[CH:28][C:6]1=2

참가 물질

5

반응물 3

HCID 1004Phosphoric AcidHCID 14798Sodium HydroxideHCID 58972533((S)-7-tert-Butoxycarbonylamino-6-oxo-6,7-dihydro-dibenzo[b,d]azepin-5-yl)-acetic acid methyl ester

생성물 1

HCID 58972470HCID 58972470, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

((S)-7-tert-Butoxycarbonylamino-6-oxo-6,7-dihydro-dibenzo[b,d]azepin-5-yl)-acetic acid methyl ester (60 mg, 0.15 mmol) were dissolved in dichloromethane (3 ml), treated with 0.15 ml (2.3 mmol) orthophosphoric acid and stirred for 18 .h The reaction mixture is adjusted to pH 7.5 with 2N aqueous sodium hydroxide, diluted with dichloromethane (5 ml) and the phases separated. After extraction of the organic phases with water (5 ml) and saturated aqueous sodium chloride (5 ml), the solution is dried with magnesium sulfate and evaporated to dryness. White solid (60%); MS: m/e=297(M+H+), which was used without further purification.

후처리

  1. customthe phases separated
  2. extractionAfter extraction of the organic phases with water (5 ml) and saturated aqueous sodium chloride (5 ml)
  3. dry with materialthe solution is dried with magnesium sulfate
  4. customevaporated to dryness
  5. customMS: m/e=297(M+H+), which was used without further purification

출처 및 근거

ORD 기록
ord-50155863f6ec4ac090cace69e4b37baf
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425551B2

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