Dichloromethane → 4-bromo-N'-(2,2-dimethylpropanoyl)benzohydrazide

HRID 31421

반응식

HRID 31421 반응식
C(O[C:6]([NH:8][NH2:9])=[O:7])(C)(C)C.[Br:10][C:11]1[CH:19]=[CH:18][C:14]([C:15](Cl)=[O:16])=[CH:13][CH:12]=1.CCN([CH:26]([CH3:28])[CH3:27])C(C)C.[Cl-].[NH4+].[CH2:31](Cl)Cl>>[CH3:27][C:26]([CH3:28])([CH3:31])[C:6]([NH:8][NH:9][C:15](=[O:16])[C:14]1[CH:18]=[CH:19][C:11]([Br:10])=[CH:12][CH:13]=1)=[O:7]

참가 물질

6

반응물 5

HCID 6344DichloromethaneHCID 25517Ammonium ChlorideHCID 685154-Bromobenzoyl chlorideHCID 70091tert-Butyl carbazateHCID 81531Diisopropylethylamine

생성물 1

HCID 47826934-bromo-N'-(2,2-dimethylpropanoyl)benzohydrazide

실험 절차

t-Butyloxycarbonylhydrazine (1.26 g) was added portionwise to a solution of 4-bromobenzoyl chloride (2.0 g), and DIPEA (2.37 ml) in DCM (20 ml) and the reaction stirred at room temperature for 18 hours. Ammonium chloride solution was added, the organic phase was separated, dried and the solvent evaporated under vacuum to give 4-bromo-benzoic acid N′-(2,2-dimethyl-propionyl)-hydrazide.

후처리

  1. customthe organic phase was separated
  2. customdried
  3. customthe solvent evaporated under vacuum

출처 및 근거

ORD 기록
ord-8132fc3f3dc447e5b26609efe5f81896
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425555B2

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