Imidazole → Tert-butyl(chroman-4-yloxy)dimethylsilane

HRID 32064

반응식

HRID 32064 반응식
[C:1]([Si:5](Cl)([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2].[O:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]([OH:19])[CH2:11][CH2:10]1.CN1CCOCC1.N1C=CN=C1>C(Cl)Cl>[C:1]([Si:5]([O:19][CH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11]1)([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2]

참가 물질

6

반응물 4

HCID 795ImidazoleHCID 79724-MethylmorpholineHCID 28928tert-Butyldimethylsilyl chlorideHCID 92890Chroman-4-ol

생성물 1

HCID 18448670Tert-butyl(chroman-4-yloxy)dimethylsilane

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

tert-Butyl-chloro-dimethyl-silane (10.54 g, 70 mmol) was added to a CH2Cl2 (200 mL) solution of 4-chromanol (10.00 g, 66.6 mmol), N-methylmorpholine (10.98 mL, 100 mmol) and imidazole (0.20 g, 3 mmol) at 0° C. The mixture was stirred for 3 days at RT. The reaction was diluted with CH2Cl2 (200 mL), washed with dilute HCl and H2O, dried over MgSO4, filtered, and concentrated in vacuo to provide the title compound.

후처리

  1. washwashed with dilute HCl and H2O
  2. dry with materialdried over MgSO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8fbaecf91b4346379115785c32c01434
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07425631B2

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