1,3-Dichloroacetone → 2-(4-Benzyloxy-phenyl)-4-chloromethyl-oxazole

HRID 322262

반응식

HRID 322262 반응식
[CH2:1]([O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:18][CH2:19][C:20]([CH2:22]Cl)=O>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]2[O:14][CH:22]=[C:20]([CH2:19][Cl:18])[N:15]=2)=[CH:16][CH:17]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 107931,3-DichloroacetoneHCID 27264314-Benzyloxybenzamide

생성물 1

HCID 220098452-(4-Benzyloxy-phenyl)-4-chloromethyl-oxazole수율 33%

실험 절차

In substantially the same manner as in Reference Example 31, 4-benzyloxybenzamide was allowed to react with 1,3-dichloroacetone to give 2-(4-benzyloxyphenyl)-4-chloromethyloxazole. The yield was 33%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 119-120° C.

출처 및 근거

ORD 기록
ord-c866ceb1ade34cdda156129c141a786c
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06211215B1

연결된 노트

불러오는 중…