Hydrochloric Acid → 2-Methylthio-5-(1H-tetrazol-1-yl)benzoic Acid
반응식
[CH3:1][S:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([O:7]C)=[O:6].[OH-].[Na+].Cl>CO>[CH3:1][S:2][C:3]1[CH:12]=[CH:11][C:10]([N:13]2[CH:17]=[N:16][N:15]=[N:14]2)=[CH:9][C:4]=1[C:5]([OH:7])=[O:6]참가 물질
5
실험 절차
Combine methyl 2-methylthio-5-(1H-tetrazol-1-yl)benzoate (0.5 g, 2.0 mmol) and a 1 M aqueous solution of sodium hydroxide (20 mL, 20 mmol) in methanol (20 mL). After 2 hours, adjust the pH to about 2 using a 1 M aqueous hydrochloric acid solution and extract with ethyl acetate. Dry the organic layer over MgSO4, filter, and concentrate in vacuo to give the title compound: Rf=0.70 (silica gel, 10% methanol/85% chloroform/5% acetic acid).
후처리
- extractionextract with ethyl acetate
- dry with materialDry the organic layer over MgSO4
- filtrationfilter
- concentrationconcentrate in vacuo
출처 및 근거
- ORD 기록
- ord-d0d6eefb850b4446b80dfda7c4d78d3b
- 출처 데이터셋
- uspto-grants-2001_04
- 특허 번호
- US06211199B1
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