Triphenylphosphine → 3-Amino-1-(diphenylmethyl)azetidine

HRID 323605

반응식

HRID 323605 반응식
[N:1]([CH:4]1[CH2:7][N:6]([CH:8]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:5]1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>O>[CH:8]([N:6]1[CH2:7][CH:4]([NH2:1])[CH2:5]1)([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 155126523-Azido-1-benzhydrylazetidine

생성물 1

HCID 57445463-Amino-1-(diphenylmethyl)azetidine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 10 (5.7 g, 21.6 mmol), triphenylphosphine (11.3 g, 43 mmol) and water (5 ml) was heated to reflux for 24 hours. After cooling to room temperature the solvent was removed in vacuo and the residue purified by chromatography on silica gel (90:9:1 CHCl3:MeOH:NH4OH).

후처리

  1. temperatureto reflux for 24 hours
  2. customwas removed in vacuo
  3. customthe residue purified by chromatography on silica gel (90:9:1 CHCl3:MeOH:NH4OH)

출처 및 근거

ORD 기록
ord-f60b66a271f9493a9e18eb43c1e0e25d
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06214832B1

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