Sodium Sulfite → 6-Methoxynicotinic acid

HRID 324516

반응식

HRID 324516 반응식
[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([CH:9]=[O:10])=[CH:5][CH:4]=1.[Mn]([O-])(=O)(=O)=[O:12].[K+].S([O-])([O-])=O.[Na+].[Na+]>C(O)(C)(C)C.O>[CH3:1][O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]([OH:12])=[O:10])=[CH:5][CH:4]=1

참가 물질

6

반응물 3

HCID 24437Sodium SulfiteHCID 516875Potassium PermanganateHCID 33645766-Methoxypyridine-3-carbaldehyde

생성물 1

HCID 5924996-Methoxynicotinic acid

시약·촉매·용매 2

HCID 962Water용매HCID 6386tert-Butanol용매

실험 절차

To a solution of 6-methoxy-3-pyridinecarboxaldehyde (50 mg, 0.36 mmol; prepared according to the method of Comins and Killpack, J. Org. Chem., 1990, 55, 69-73) in t-butanol (0.5 ml) was added a solution of potassium permanganate (81 mg) in water (1.0 ml). The mixture was stirred at room temperature for two hours, and then saturated sodium sulphite solution was added until the purple colour disappeared. Reaction mixture was extracted with chloroform several times as it was gradually acidified with dilute HCl (2N). Chloroform extracts were concentrated in vacuo to yield the title compound (42 mg) as a white solid.

후처리

  1. customprepared
  2. customReaction mixture
  3. extractionwas extracted with chloroform several times as it
  4. concentrationChloroform extracts were concentrated in vacuo

출처 및 근거

ORD 기록
ord-609ffab1efe6406692f63a5091ffb537
출처 데이터셋
uspto-grants-2001_04
특허 번호
US06218393B1

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