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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Cyclohexanol → 9-Cyclohexyl-8-(1-methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine

HRID 32546
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HRID 32546 반응식
N(C(OC(C)C)=O)=NC(OC(C)C)=O.[CH3:15][N:16]1[C:20]([C:21]2[NH:22][C:23]3[C:28]([N:29]=2)=[C:27]([NH2:30])[N:26]=[CH:25][N:24]=3)=[C:19]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[N:18]=[CH:17]1.[CH:37]1(O)[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[CH:37]1([N:22]2[C:21]([C:20]3[N:16]([CH3:15])[CH:17]=[N:18][C:19]=3[C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[N:29][C:28]3[C:23]2=[N:24][CH:25]=[N:26][C:27]=3[NH2:30])[CH2:42][CH2:41][CH2:40][CH2:39][CH2:38]1
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참가 물질

6

반응물 4

HCID 7966CyclohexanolHCID 11776TriphenylphosphineHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 178481246HCID 178481246, 화합물

생성물 1

HCID 103619899-Cyclohexyl-8-(1-methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine수율 11%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

Diisopropyl azodicarboxylate (0.1 mL) was added to a solution of 8-(1-methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine (Example 3) (75 mg), cyclohexanol (0.07 mL) and triphenylphosphine (0.14 g) in THF (4 mL) under an inert atmosphere. After stirring at ambient temperature for 48 hours the reaction mixture was heated at 40° C. for 48 hours and then at 55° C. for 24 hours. The solvent was then evaporated in vacuo to give a brown oil. Purification by preparative LCMS gave the title compound as a white solid (11 mg, 11%);

후처리

  1. temperaturewas heated at 40° C. for 48 hours
  2. waitat 55° C. for 24 hours
  3. customThe solvent was then evaporated in vacuo
  4. customto give a brown oil
  5. customPurification by preparative LCMS

출처 및 근거

ORD 기록
ord-d48c83fc7ad5411db027175bd48b26b8
출처 데이터셋
uspto-grants-2008_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07427616B2

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