Propargyl bromide → 2-(Prop-2-yn-1-yloxy)benzene-1-sulfonamide

HRID 325799

반응식

HRID 325799 반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[C:19]#[CH:20]>CC(CC)=O>[CH2:20]([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:9])=[O:10])[C:19]#[CH:18]

참가 물질

5

반응물 3

HCID 7842Propargyl bromideHCID 11430Potassium CarbonateHCID 6375462-Hydroxybenzene-1-sulfonamide

생성물 1

HCID 134729452-(Prop-2-yn-1-yloxy)benzene-1-sulfonamide

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

A mixture of 35 g of 2-hydroxyphenylsulfonamide, 55.2 g of potassium carbonate, 15.5 ml of propargyl bromide and 1000 ml of ethyl methyl ketone is refluxed for 1.5 hours; it is then cooled, filtered, and concentrated by evaporation. The yield after recrystallisation of the residue from ethyl acetate is 30 g of 2-propargyloxyphenylsulfonamide, m.p. 143°-145° C.

후처리

  1. temperatureis refluxed for 1.5 hours
  2. temperatureit is then cooled
  3. filtrationfiltered
  4. concentrationconcentrated by evaporation
  5. customThe yield
  6. customafter recrystallisation of the residue from ethyl acetate

출처 및 근거

ORD 기록
ord-47781081ac0a4e7d88cd65dc00613ba4
출처 데이터셋
uspto-grants-1984_04
특허 번호
US04443243

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