Gamma-Butyrolactone → 1-Benzyl-3-pyrrolidone

반응식

[C:1]1(=[O:6])O[CH2:4][CH2:3][CH2:2]1.[CH2:7]([NH2:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH2:7]([N:14]1[CH2:4][CH2:3][CH2:2][C:1]1=[O:6])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

반응물 2

HCID 7302Gamma-Butyrolactone

HCID 7504Benzylamine

생성물 1

HCID 791761-Benzyl-3-pyrrolidone

실험 절차

6.97 g (0.06 M) of γ-butyrolactone is mixed with 6.97 g (0.065 M) of benzylamine and heated at 190° for 24 hours. Excess benzyl amine and water was distilled off and the residue was distilled to obtain 7.4 g (70%); b.p. 125°-130°/1 mm.

후처리

temperatureheated at 190° for 24 hours
distillationExcess benzyl amine and water was distilled off
distillationthe residue was distilled
customto obtain 7.4 g (70%)

출처 및 근거

ORD 기록: ord-121e03c19d2f4123b2688134089a6b75
출처 데이터셋: uspto-grants-1984_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04444762

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