Trifluoroacetic acid → 6-[1-(4-Aminobutyl)-4-phenyl-1H-imidazol-5-yl]-thieno[2,3-d]pyrimidin-4-amine

tert-Butyl {4-[5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-4-phenyl-1H-imidazol-1-yl]butyl}carbamate (Example 173) (23 mg) was added to a mixture of TFA, water and triisopropyl silane (5:5:1) (5 ml) and stirred at ambient temperature for 1 hour. The reaction mixture was concentrated in vacuo and the residue purified by preparative RPHPLC (eluting with a gradient of MeCN and water containing 0.1% TFA) to give the title compound as a colourless solid (18 mg, 90%);

1. concentrationThe reaction mixture was concentrated in vacuo
2. customthe residue purified by preparative RPHPLC (
3. washeluting with a gradient of MeCN and water containing 0.1% TFA)

ORD 기록

ord-0c1ae98f803a4acaa727d9ddea90ba00

출처 데이터셋

uspto-grants-2008_09

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07427616B2