Benzoic Acid → 2-Chloro-5-cyclopropylmethanesulfonyl-benzoic acid

HRID 32668

반응식

HRID 32668 반응식
C(O)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=CC=1.[Cl:10][C:11]1[CH:19]=[CH:18][C:17]([S:20]([OH:22])=[O:21])=[CH:16][C:12]=1[C:13]([OH:15])=[O:14].BrCC1CC1.II>C1(CO)CC1>[Cl:10][C:11]1[CH:19]=[CH:18][C:17]([S:20]([CH2:5][CH:6]2[CH2:2][CH2:7]2)(=[O:22])=[O:21])=[CH:16][C:12]=1[C:13]([OH:15])=[O:14]

참가 물질

6

반응물 4

HCID 243Benzoic AcidHCID 807IodineHCID 81503BromomethylcyclopropaneHCID 151129042-Chloro-5-sulfino-benzoic acid

생성물 1

HCID 435605642-Chloro-5-cyclopropylmethanesulfonyl-benzoic acid수율 8%

시약·촉매·용매 1

HCID 75644Cyclopropanemethanol용매

실험 절차

The title compound was synthesised according to the procedure described for the synthesis of 2-Chloro-5-methanesulfonyl)-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and Bromomethyl-cyclopropane (+catalytic amount I2) in 20 ml cyclopropyl methanol/20 ml water and obtained in 8% yield. MS (m/e): 273.1 (MH−, 100%).

후처리

  1. customobtained in 8% yield

출처 및 근거

ORD 기록
ord-6074aae533fb4a4fa4fccb4f830f50df
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07427612B2

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