Ethyl Acetate → 2-[(2,2,2-Trifluoroethoxy)methyl]-4(3H)-pteridinone

HRID 326849

반응식

HRID 326849 반응식
N[C:2]1[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=[C:4]([CH2:12][O:13][CH2:14][C:15]([F:18])([F:17])[F:16])[N:3]=1.C(OCC)(=[O:21])C>[OH-].[Na+]>[F:16][C:15]([F:18])([F:17])[CH2:14][O:13][CH2:12][C:4]1[NH:3][C:2](=[O:21])[C:11]2[C:6](=[N:7][CH:8]=[CH:9][N:10]=2)[N:5]=1

참가 물질

4

반응물 2

HCID 8857Ethyl AcetateHCID 105391874-Amino-2-[(2,2,2-trifluoroethoxy)methyl]pteridine

생성물 1

HCID 1354172242-[(2,2,2-Trifluoroethoxy)methyl]-4(3H)-pteridinone

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

Obtained using the procedure described in section d of Example 2, starting with 5.0 g (0.0193 mole) of 4-amino-2-[(2,2,2-trifluoroethoxy)methyl]pteridine in 105 ml of 5% aqueous sodium hydroxide. Heating time: 1 hour 30 minutes at 80° C. Yld: 2.5 g (50%), m.p. 165°-167° C. (ethyl acetate).

후처리

  1. customObtained
  2. temperatureHeating time
  3. custom1 hour 30 minutes
  4. customat 80° C

출처 및 근거

ORD 기록
ord-45bbbca9bbf049fd95e47657fcfd4123
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05270465

연결된 노트

불러오는 중…