Melatonin → 2-Iodomelatonin
반응식
[CH3:1][C:2]([NH:4][CH2:5][CH2:6][C:7]1[C:11]2[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:10]=2[NH:9][CH:8]=1)=[O:3].[I:18]N1C(=O)CCC1=O>C(Cl)(Cl)Cl>[C:2]([NH:4][CH2:5][CH2:6][C:7]1[C:11]2[C:10](=[CH:15][CH:14]=[C:13]([O:16][CH3:17])[CH:12]=2)[NH:9][C:8]=1[I:18])(=[O:3])[CH3:1]참가 물질
4
반응 조건
- 온도
- -20 °C
실험 절차
To a solution of melatonin (2.32 g: 10 mM) in chloroform (70 ml) cooled at -20° C. there is added N-iodosuccinimide (NIS:2.25 g; 10 nM); the reaction mixture is stirred at -20° C. for 4.5 hours.
출처 및 근거
- ORD 기록
- ord-0f931396061d40c0820e9436235af492
- 출처 데이터셋
- uspto-grants-1993_12
- 특허 번호
- US05272141
반응 노트
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