2-(Dimethylamino)ethanol → 2-Dimethylaminoethyl isobutyrate

HRID 327268

반응식

HRID 327268 반응식
[CH3:1][N:2]([CH3:6])[CH2:3][CH2:4][OH:5].C(N(CC)CC)C.[C:14](Cl)(=[O:18])[CH:15]([CH3:17])[CH3:16].C(=O)(O)[O-].[Na+]>O.ClCCl>[C:14]([O:5][CH2:4][CH2:3][N:2]([CH3:6])[CH3:1])(=[O:18])[CH:15]([CH3:17])[CH3:16]

참가 물질

7

반응물 4

HCID 79022-(Dimethylamino)ethanolHCID 8471TriethylamineHCID 62325Isobutyryl chlorideHCID 516892Sodium Bicarbonate

생성물 1

HCID 4129962-Dimethylaminoethyl isobutyrate수율 30.9%

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

To a mechanically stirred solution of 83.66 g (94.3 mL, 0.939 mol) of 2-dimethylaminoethanol (distilled) and 95 g (131 mL) of triethylamine (Aldrich gold label) in 1L of dry dichloromethane maintained at 0° to -15° C. was added dropwise 100 g (98.3 mL, 0.939 mol) of isobutyryl chloride. The mixture was stirred 30 min at room temperature and treated with a solution of 100 g of sodium bicarbonate in water. The organic layer was washed with dilute sodium bicarbonate solution, dried with sodium sulfate and distilled to give 46.2 g of 2-dimethylaminoethyl isobutyrate, b.p. 59°-64° C. (8-10 mm). 1H-NMR (360 MHz, benzene-d6): 1.06 (d, J=6.6 Hz, 6 H, Me2CH), 2.05 (s, 6 H, CH3N), 2.33 (t, J=6 Hz, 2 H, CH2N), 2.39 (sept, J= 6.6 Hz, 1 H, Me2CH), 4.11 (t, J=6 Hz, 2 H, CH2O). Anal Calcd for C8H17NO2 : C 60.35, H 10.76, N 8.80; found: C 60.82, H 10.95, N 9.01.

후처리

  1. washThe organic layer was washed with dilute sodium bicarbonate solution
  2. dry with materialdried with sodium sulfate
  3. distillationdistilled

출처 및 근거

ORD 기록
ord-729bc84ffa8b498bbfc23e1de82309b4
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05272201

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