1-Dodecanol → Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

HRID 327272

반응식

HRID 327272 반응식
[CH2:1]1[O:8]C(=O)C[O:4][C:2]1=[O:3].[CH3:9][C@@H:10]1[O:17]C(=O)[C@H](C)[O:13][C:11]1=[O:12].CCCCC(C([O-])=O)CC.CCCCC(C([O-])=O)CC.[Sn+2].C(O)CCCCCCCCCCC>C1(C)C=CC=CC=1>[C:2]([OH:4])(=[O:3])[CH2:1][OH:8].[C:11]([OH:13])(=[O:12])[CH:10]([CH3:9])[OH:17]

참가 물질

6

반응물 4

HCID 81931-DodecanolHCID 93182-ethylhexanoic acid tin(II) saltHCID 65432GlycolideHCID 107983Lactide, L-

생성물 1

HCID 36797Hydroxyacetic acid--2-hydroxypropanoic acid (1/1)

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
220 °C

실험 절차

1161 g (10 mols) of glycolide and 1441 g (10 mols) of L-lactide were placed in a glass reactor, and 10 ml of a toluene solution containing 0.26 g of stannous octoate and 9.0 g of lauryl alcohol were added to the reactor. Afterward, deaeration was carried out for 2 hours under reduced pressure, and the atmosphere in the reactor was then replaced with a nitrogen gas. This mixture was heated at 220° C. for 2 hours with stirring under the nitrogen atmosphere. While the temperature was maintained as it was, the deaeration was slowly performed by means of a vacuum pump through an exhaust pipe to reduce the pressure in the reactor to 3 mm Hg. One hour after the start of the deaeration, the monomers and low-molecular substances were not extracted any more, and the interior of the reactor was replaced with nitrogen and a resultant glycolic acid-lactic acid copolymer (hereinafter referred to as "PLGA") was then taken out.

후처리

  1. additionwere added to the reactor
  2. temperatureWhile the temperature was maintained as it
  3. extractionOne hour after the start of the deaeration, the monomers and low-molecular substances were not extracted any more, and the interior of the reactor

출처 및 근거

ORD 기록
ord-1521c8617741434ebf5cc202e22761c1
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05272221

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