Acetic Anhydride → HCID 12838038, 화합물

HRID 327402노트

반응식

HRID 327402 반응식
Cl.[Cl:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][NH:10][CH2:9][CH2:8]2.[OH-].[Na+].C([O-])(O)=O.[Na+].[C:20](OC(=O)C)(=[O:22])[CH3:21]>ClCCl>[C:20]([N:10]1[CH2:9][CH2:8][C:7]2[C:12](=[C:3]([Cl:2])[CH:4]=[CH:5][CH:6]=2)[CH2:11]1)(=[O:22])[CH3:21]

참가 물질

6

반응물 4

HCID 7918Acetic AnhydrideHCID 14798Sodium HydroxideHCID 516892Sodium BicarbonateHCID 125950728-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride

생성물 1

HCID 12838038HCID 12838038, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 28.6 g of 8-chloro-1,2,3,4-tetrahydoisoquinoline hydrochloride in 140 ml of dichloromethane was added 140 ml of 1N aqueous NaOH solution and 17.6 g of NaHCO3. To the solution was added dropwise 14.5 ml of acetic anhydride at 5° C. The mixture was stirred at room temperature for 1 hour. The organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic extracts were washed with water, dried over anhydrous sodium sulfate. The solvent was distilled off to give 29.1 g of the title compound as a pale red oil.

후처리

  1. customThe organic layer was separated
  2. extractionthe aqueous layer was extracted with dichloromethane
  3. washThe combined organic extracts were washed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. distillationThe solvent was distilled off

출처 및 근거

ORD 기록
ord-95ad5da48c2b4f3eac985c169b57df40
출처 데이터셋
uspto-grants-1993_12
특허 번호
US05273974

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