Propionic Acid → ((S)-Dihydro-2,5-dioxo-3-furyl)ammonium chloride

반응식

[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][C:4]([OH:6])=O.C(O)(=O)CC.P(Cl)(Cl)[Cl:16].C(OC(=O)C)(=O)C>>[ClH:16].[NH2:1][C@@H:2]1[C:7](=[O:8])[O:9][C:4](=[O:6])[CH2:3]1

참가 물질

반응물 4

HCID 1032Propionic Acid

HCID 5960L-Aspartic Acid

HCID 7918Acetic Anhydride

HCID 24387Phosphorus trichloride

생성물 1

HCID 44147132((S)-Dihydro-2,5-dioxo-3-furyl)ammonium chloride

실험 절차

To a suspension of 10 g. of L-aspartic acid in 40 ml. of propionic acid is added, at room temperature with stirring, 3.8 g. of phosphorous trichloride and stirring is continued at that temperature for about 1 1/2 hours. At the end of that time, 5 g. of acetic anhydride is added and the reaction mixture is stirred at room temperature for approximately 8 hours longer. The crystals which separate from the reaction mixture are filtered, washed with ether and dried to afford L-aspartic acid anhydride hydrochloride.

후처리

additionTo a suspension of 10 g
customis continued at that temperature for about 1 1/2 hours
stirringthe reaction mixture is stirred at room temperature for approximately 8 hours longer
customThe crystals which separate from the reaction mixture
filtrationare filtered
washwashed with ether
customdried

출처 및 근거

ORD 기록: ord-7ecfad1c0e2a40b7b54dbac96a0f0460
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04017472

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