Sodium Hydroxide → 1-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol

HRID 328889

반응식

HRID 328889 반응식
[CH:1]([N:4]1[CH2:7][CH:6]([OH:8])[CH2:5]1)([CH3:3])[CH3:2].[O:9]([C:16]1(O)[CH:21]=[CH:20][CH:19]=[CH:18][CH2:17]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[OH-:23].[Na+]>>[O:9]([C:16]1[CH:21]=[CH:20][C:19]([O:23][CH2:5][CH:6]([OH:8])[CH2:7][NH:4][CH:1]([CH3:2])[CH3:3])=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 5446771-(Propan-2-yl)azetidin-3-olHCID 205173521-Phenoxyphenol

생성물 1

HCID 205173151-(p-Phenoxyphenoxy)-3-(iso-propylamino)-2-propanol수율 58%

반응 조건

온도
160 °C

실험 절차

To a mixture of 5.8 parts of 1-(iso-propyl)-3-azetidinol and 9.3 parts of 1-phenoxyphenol 0.1 part of sodium hydroxide was added, and the mixture was heated under nitrogen gas at 160° C. for 18 hours. The reaction mixture was cooled and extracted with ether. The extract was washed in water and then the solvent was distilled off. Recrystallization of the residue gave 16.1 parts of 1-(p-phenoxyphenoxy)-3-(iso-propylamino)-2-propanol having a melting point of 72°-74° C. The yield was 58%.

후처리

  1. additionwas added
  2. temperatureThe reaction mixture was cooled
  3. extractionextracted with ether
  4. washThe extract was washed in water
  5. distillationthe solvent was distilled off
  6. customRecrystallization of the residue

출처 및 근거

ORD 기록
ord-439dc4399852448982e7db8374c60e24
출처 데이터셋
uspto-grants-1977_04
특허 번호
US04018824

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