Hydrogen Bromide → 1,4-Dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

반응식

[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[N:4]=[C:3]1[CH2:8]O.Cl.[NH2:11][CH2:12][CH2:13][SH:14].[BrH:15]>>[BrH:15].[BrH:15].[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[N:4]=[C:3]1[CH2:8][S:14][CH2:13][CH2:12][NH2:11]

참가 물질

반응물 3

HCID 260Hydrogen Bromide

HCID 9082Cysteamine Hydrochloride

HCID 12923402(1,4-dimethyl-1H-imidazol-2-yl)methanol

생성물 1

HCID 205579691,4-Dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide

실험 절차

The reaction of 1,4-dimethyl-2-hydroxymethylimidazole (2.5 g.) with cysteamine hydrochloride (2.5 g.) in aqueous hydrobromic acid by the method described in Example 1 (i) (a) gave 1,4-dimethyl-2-[(2-aminoethyl)thiomethyl]imidazole dihydrobromide (6.2 g.) m.p. 161°-163° (from isopropyl alcohol-methoanol).

출처 및 근거

ORD 기록: ord-27d6c2b808bc40f1a49850db58ead8c1
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04018931

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