Ethylenediamine → N-Methyl-N'-[2-(2-thiazolylmethylamino)ethyl]urea

HRID 329112노트

반응식

[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][NH:7][CH2:8][CH2:9][NH2:10].C(N)CN.ClCC1SC=CN=1.[CH3:22][N:23]=[C:24]=[O:25]>>[CH3:22][NH:23][C:24]([NH:10][CH2:9][CH2:8][NH:7][CH2:6][C:2]1[S:1][CH:5]=[CH:4][N:3]=1)=[O:25]

참가 물질

반응물 4

HCID 3301Ethylenediamine

HCID 12228Methyl Isocyanate

HCID 140908642-(Chloromethyl)-1,3-thiazole

HCID 17944882N-(2-thiazolylmethyl)ethylenediamine

생성물 1

HCID 20557949N-Methyl-N'-[2-(2-thiazolylmethylamino)ethyl]urea

실험 절차

N-(2-Thiazolylmethyl)ethylenediamine, prepared by reacting ethylenediamine with 2-chloromethylthiazole by the procedure of Example 40, is reacted with methyl isocyanate by the procedure of Example 24 to give, after concentrating and separating by column chromatography, the title compound.

후처리

customto give
concentrationafter concentrating
customseparating by column chromatography

출처 및 근거

ORD 기록: ord-306d0135d0694b778acdfaa42317621d
출처 데이터셋: uspto-grants-1977_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04018931

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