홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Iodoethane → Isopropyl 4-(3-chloro-2-thienyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate

HRID 329938
노트
인쇄 미리보기

반응식

HRID 329938 반응식
[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[C:12]([C:13]([O:15][CH:16]([CH3:18])[CH3:17])=[O:14])=[C:11]([CH3:19])[NH:10][C:9]2[CH2:20][O:21][C:22](=[O:23])[C:8]1=2.[H-].[Na+].[CH2:26](I)[CH3:27]>CN(C)C=O>[Cl:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[CH:7]1[C:12]([C:13]([O:15][CH:16]([CH3:17])[CH3:18])=[O:14])=[C:11]([CH3:19])[N:10]([CH2:26][CH3:27])[C:9]2[CH2:20][O:21][C:22](=[O:23])[C:8]1=2
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 13853275Isopropyl 4-(3-chloro-2-thienyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]-pyridine-3-carboxylate

생성물 1

HCID 13853276Isopropyl 4-(3-chloro-2-thienyl)-1-ethyl-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

10 mmol of isopropyl 4-(3-chloro-2-thienyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3.4-b]pyridine-3-carboxylate are dissolved in 25 ml of dimethylformamide and deprotonated with NaH, and 20 mmol of ethyl iodide are added. After the mixture has been stirred at room temperature for 1 hour, it is concentrated, water is added to the residue and the product is filtered off with suction and recrystallized from methanol.

후처리

  1. additionare added
  2. concentrationit is concentrated
  3. additionwater is added to the residue
  4. filtrationthe product is filtered off with suction
  5. customrecrystallized from methanol

출처 및 근거

ORD 기록
ord-a9bba68bd74e43c69c0dfd3570c7b02f
출처 데이터셋
uspto-grants-1990_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04894378

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트