Benzaldehyde → Beta-Nitrostyrene

HRID 3305

반응식

HRID 3305 반응식
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:9]([CH3:12])([O-:11])=[O:10].[OH-].[Na+].Cl>CO>[C:2]1([CH:1]=[CH:12][N+:9]([O-:11])=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 6375NitromethaneHCID 14798Sodium Hydroxide

생성물 1

HCID 7626Beta-Nitrostyrene수율 37%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
-18 °C

실험 절차

Benzaldehyde (10.0 g, 94.2 mmol) and nitromethane (5.1 mL, 94.2 mmol) were dissolved in MeOH, the solution was cooled to -18° C., and NaOH (3.9 g, 98.9 mmol) in aqueous solution (80 mL) was added while maintaining the temperature below -10° C. The mixture was stirred at 0° C. for 2 hours, then stored at 5° C. overnight. The solution was then poured into stirring acid (200 mL conc. HCl/300 mL H2O). The precipitate was collected, washed, and recrystallized from EtOH to afford the title compound as light orange needles (5.15 g, 37%).

후처리

  1. temperaturewhile maintaining the temperature below -10° C
  2. waitstored at 5° C. overnight
  3. additionThe solution was then poured
  4. customThe precipitate was collected
  5. washwashed
  6. customrecrystallized from EtOH

출처 및 근거

ORD 기록
ord-e4c5a915e9a24293aae0af7d3e5b3bcb
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733912

연결된 노트

불러오는 중…