Hydrochloric Acid → 2-Amino-4-bromo-5-fluorobenzoic acid hydrochloride
반응식
[Br:1][C:2]1[C:10]([F:11])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([N+:12]([O-])=O)[CH:3]=1.Cl.[Sn](Cl)[Cl:17]>O>[ClH:17].[NH2:12][C:4]1[CH:3]=[C:2]([Br:1])[C:10]([F:11])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
To a mixture of 4-bromo-5-fluoro-2-nitrobenzoic acid (10 g, 37.9 mmol) and HCl (70 mL, 852 mmol) in water (70 mL) was added tin(II) chloride (21.55 g, 114 mmol) and the mixture was then heated at 90° C. for 3 hours. After cooling to RT, the formed precipitate was filtered, washed with water and collected to give title compound (8.51 g). LCMS (A): m/z [(M−HCl)+H]+ 234/236, C7H5BrFNO2.HCl requires 269/271 (acidic).
후처리
- temperatureAfter cooling to RT
- filtrationthe formed precipitate was filtered
- washwashed with water
- customcollected
출처 및 근거
- ORD 기록
- ord-05bc856972c04e4f88b6129307b3a6a3
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08877742B2
반응 노트
불러오는 중…