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Hydrochloric Acid → N,N-dimethyl-1-[6-(1-naphthylsulfonyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indazol-2-yl]methanamine Hydrochloride

HRID 33111
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인쇄 미리보기

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HRID 33111 반응식
[Cl:1][CH2:2][CH:3]1[CH2:13][N:12]2[C:14]3[C:9]([C:10]([S:15]([C:18]4[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=5)[CH:21]=[CH:20][CH:19]=4)(=[O:17])=[O:16])=[N:11]2)=[CH:8][CH:7]=[CH:6][C:5]=3[O:4]1.[CH3:28][NH:29][CH3:30].Cl.CCOCC>CS(C)=O.O>[ClH:1].[CH3:28][N:29]([CH3:30])[CH2:2][CH:3]1[O:4][C:5]2=[C:14]3[C:9](=[CH:8][CH:7]=[CH:6]2)[C:10]([S:15]([C:18]2[C:27]4[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH:21]=[CH:20][CH:19]=2)(=[O:17])=[O:16])=[N:11][N:12]3[CH2:13]1
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참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 3283Diethyl EtherHCID 251690347-Chloromethyl-2(naphthalene-1-sulfonyl)-7,8-dihydro-6-oxa-1,8a-diaza-acenaphthylene

생성물 1

HCID 25169296N,N-dimethyl-1-[6-(1-naphthylsulfonyl)-2,3-dihydro[1,4]oxazino[2,3,4-hi]indazol-2-yl]methanamine Hydrochloride

시약·촉매·용매 2

HCID 679
Dimethyl Sulfoxide
용매
HCID 962Water용매

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온도
100 °C

실험 절차

A mixture of 7-chloromethyl-2-(naphthalene-1-sulfonyl)-7,8-dihydro-6-oxa-1,8a-diaza-acenaphthylene (0.075 g, 0.18 mmoles) and dimethylamine (0.56 ml, 1M solution in THF, 0.56 mmoles) in DMSO was stirred under nitrogen at 100° C. for 4 hours, cooled to room temperature, diluted with water and extracted with EtOAc. The extracts were combined, washed sequentially with water and brine, dried over Na2SO4 and concentrated under vacuum. The resultant residue was purified by flash chromatography using as eluent 5% CH3OH/EtOAc. The purified compound was dissolved in methanol, treated with 1M HCl in ether (0.2 ml, 0.2 mmoles) and evaporated to dryness to afford the title compound, MS: (ES) m/z 407.

후처리

  1. temperaturecooled to room temperature
  2. extractionextracted with EtOAc
  3. washwashed sequentially with water and brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under vacuum
  6. customThe resultant residue was purified by flash chromatography
  7. dissolutionThe purified compound was dissolved in methanol
  8. customevaporated to dryness

출처 및 근거

ORD 기록
ord-54107132d07d48338dc750a18208c17c
출처 데이터셋
uspto-grants-2008_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07429582B2

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