Magnesium chloride hexahydrate → Vildagliptin Magnesium(II)-Chloride

HRID 332076

반응식

HRID 332076 반응식
O.O.O.O.O.O.[Cl-:7].[Mg+2:8].[Cl-].[CH2:10]1[CH2:14][N:13]([C:15]([CH2:17][NH:18][C:19]23[CH2:28][C:26]4([OH:29])[CH2:27][CH:21]([CH2:22][CH:23]([CH2:25]4)[CH2:24]2)[CH2:20]3)=[O:16])[C@H:12]([C:30]#[N:31])[CH2:11]1>CC(O)C>[CH2:10]1[CH2:14][N:13]([C:15]([CH2:17][NH:18][C:19]23[CH2:28][C:26]4([OH:29])[CH2:25][CH:23]([CH2:22][CH:21]([CH2:27]4)[CH2:20]2)[CH2:24]3)=[O:16])[C@H:12]([C:30]#[N:31])[CH2:11]1.[Cl-:7].[Mg+2:8].[Cl-:7]

참가 물질

4

반응물 2

HCID 24644Magnesium chloride hexahydrateHCID 6918537Vildagliptin

생성물 1

HCID 86675510Vildagliptin Magnesium(II)-Chloride

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

0.34 g (1.65 mmole) of magnesium(II)-chloride hexahydrate is dissolved in 15 cm3 of 2-propanol at 50° C. under intensive stirring, and 1.0 g (3.3 mmole) of vildagliptin base is added to the solution. The solution is stirred at room temperature for 2 hours and is subsequently evaporated. The remaining crystalline product is washed with propanol and dried.

후처리

  1. additionis added to the solution
  2. customis subsequently evaporated
  3. washThe remaining crystalline product is washed with propanol
  4. customdried

출처 및 근거

ORD 기록
ord-c451687bab2a46079dfc833dbed04ae3
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877799B2

연결된 노트

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