Hydrochloric Acid → (S)-3-(1,3-Dioxolan-2-yl)propyl 2-amino-3-phenylpropanoate

HRID 332694

반응식

HRID 332694 반응식
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl[CH2:21][CH2:22][CH2:23][CH:24]1[O:28][CH2:27][CH2:26][O:25]1.Cl>O1CCOCC1>[NH2:1][C@@H:2]([CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1)[C:10]([O:12][CH2:21][CH2:22][CH2:23][CH:24]1[O:28][CH2:27][CH2:26][O:25]1)=[O:11]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 77857L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-HCID 5520722-(3-Chloropropyl)-1,3-dioxolane

생성물 1

HCID 71113124(S)-3-(1,3-Dioxolan-2-yl)propyl 2-amino-3-phenylpropanoate

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

The title compound was prepared in two steps. Boc-Phe-OH was reacted with 2-(3-chloropropyl)-1,3-dioxolane according to Example 10 Step 1, and the subsequent product reacted with hydrogen chloride in dioxan according to Example 79 Step 5.

출처 및 근거

ORD 기록
ord-981eb4ca7d664fe68fd01923aa795e02
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877774B2

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