Iodoethane → 6-ethyl-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

HRID 333415노트

반응식

HRID 333415 반응식
[O:1]=[C:2]1[N:7]2[CH:8]=[N:9][CH:10]=[C:6]2[CH2:5][CH2:4][NH:3]1.[H-].[Na+].I[CH2:14][CH3:15]>CN(C=O)C>[CH2:14]([N:3]1[CH2:4][CH2:5][C:6]2=[CH:10][N:9]=[CH:8][N:7]2[C:2]1=[O:1])[CH3:15]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 24758Sodium hydrideHCID 14875185H,6H,7H,8H-imidazo(1,5-c)pyrimidin-5-one

생성물 1

HCID 126472846-ethyl-7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 500 mg (3.6 mmol) of 5,6,7,8-tetrahydro-5-oxoimidazo[1,5-c]pyrimidine dissolved in 5 mL of DMF are added cautiously at room temperature 173 mg (4.32 mmol) of sodium hydride. The reaction medium is stirred for 1 hour at room temperature, and 0.35 mL (4.32 mmol) of iodoethane is then added dropwise. The reaction medium is stirred for 2 hours at room temperature and the solvents are then evaporated off. The residue is treated with 1N NaHCO3 solution and extracted with chloroform. The combined organic phases are dried with MgSO4, filtered and evaporated. The oil obtained is used directly in the following step.

후처리

  1. stirringThe reaction medium is stirred for 2 hours at room temperature
  2. customthe solvents are then evaporated off
  3. additionThe residue is treated with 1N NaHCO3 solution
  4. extractionextracted with chloroform
  5. dry with materialThe combined organic phases are dried with MgSO4
  6. filtrationfiltered
  7. customevaporated
  8. customThe oil obtained

출처 및 근거

ORD 기록
ord-b9fc3996d22b4207a971a1dc312ba64b
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08877968B2

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