Hydrochloric Acid → HCID 178462804, 화합물

HRID 333552노트

반응식

HRID 333552 반응식
[CH2:1]([NH:3][C:4]1[C:9]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=[CH:6][N:5]=1)C.[ClH:17].C(O[CH2:26][CH3:27])(OCC)OCC>C(O)=O>[Cl:17][N+:3]1([CH2:26][CH3:27])[C:4]2=[N:5][CH:6]=[CH:7][CH:8]=[C:9]2[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH-:1]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 31214Ethyl orthoformateHCID 70665410HCID 70665410, 화합물

생성물 1

HCID 178462804HCID 178462804, 화합물수율 91%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

N2-ethyl-N3-phenylpyridine-2,3-diamine (8.5 g, 40 mmol), concentrated HCl (6 mL), and 4 mL of formic acid were added to the triethyl orthoformate (376 mL). The reaction was refluxed overnight. After it cooled to room temperature, the beige solid was collected by filtration. The solid was further purified by recrystallizing from ethanol to give 3-chloro-3-ethyl-1-phenyl-2,3-dihydro-1H-imidazo[4,5-b]pyridin-3-ium-2-ide (9.4 g, 91% yield).

후처리

  1. temperatureThe reaction was refluxed overnight
  2. filtrationthe beige solid was collected by filtration
  3. customThe solid was further purified
  4. customby recrystallizing from ethanol

출처 및 근거

ORD 기록
ord-e6aa036cc27a441ca968d25f2050ce80
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08883322B2

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