Hydrochloric Acid → (RS)-2-bromo-6-(1-hydroxyheptyl)anisole
반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Br:8])[C:3]=1[O:9][CH3:10].[CH:11](=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].Cl>C1COCC1>[Br:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH:11]([OH:18])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:3]=1[O:9][CH3:10]참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
To a THF solution of 2,6-dibromoanisole (10 g, 37.6 mmol) was added Mg (0.90 g, 37.6 mmol), and the mixture was heated and stirred at 40° C. Under ice-cooling, n-heptanal (47.2 g, 41.3 mmol) was added dropwise. Aqueous hydrochloric acid solution was added to the reaction mixture, this was extracted with ethyl acetate, and the solvent was distilled off to obtain 8.95 g of a compound (1).
후처리
- temperaturethe mixture was heated
- temperatureUnder ice-cooling
- extractionthis was extracted with ethyl acetate
- distillationthe solvent was distilled off
출처 및 근거
- ORD 기록
- ord-53e03c4968f94623a0aa01cae23e16bf
- 출처 데이터셋
- uspto-grants-2014_11
- 특허 번호
- US08889722B2
반응 노트
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