4-Aminobenzoic Acid → HCID 67078597, 화합물

HRID 338615

반응식

HRID 338615 반응식
[CH:1]1N=C[N:3]([C:6]([N:8]2C=N[CH:10]=[CH:9]2)=[O:7])[CH:2]=1.[CH3:13][O:14][C:15]1[CH:16]=C([CH:20]=[C:21]([O:25][CH3:26])[C:22]=1[O:23][CH3:24])CN.NC1[CH:36]=[CH:35][C:31]([C:32]([OH:34])=[O:33])=[CH:30][CH:29]=1>[OH-].[Na+]>[CH3:26][O:25][C:21]1[CH:20]=[C:10]([CH:16]=[C:15]([O:14][CH3:13])[C:22]=1[O:23][CH3:24])[CH2:9][NH:8][C:6](=[O:7])[NH:3][CH2:2][C:1]1[CH:36]=[CH:35][C:31]([C:32]([OH:34])=[O:33])=[CH:30][CH:29]=1

참가 물질

5

반응물 3

HCID 9784-Aminobenzoic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 877363,4,5-Trimethoxybenzylamine

생성물 1

HCID 67078597HCID 67078597, 화합물수율 94.6%

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

실험 절차

N,N-carbonyldiimidazole (1.62 g, 10 mmol), 3,4,5-trimethoxybenzyl amine (1.97 g, 10 mmol), p-aminobenzoic acid (1.52 g, 10 mmol), and 10 ml of 1 mol/L sodium hydroxide are used according to the method for the production of compound III in Method two to obtain 3.54 g of 4-[(3,4,5-trimethoxybenzylureido)methyl]benzoic acid (intermediate M-35) as a white solid, with a yield of 94.6%.

출처 및 근거

ORD 기록
ord-3d01f9b77e7e44969a51c2bde6985c6f
출처 데이터셋
uspto-grants-2014_11
특허 번호
US08889876B2

연결된 노트

불러오는 중…