Hydrochloric Acid → HCID 59797049, 화합물

HRID 34043노트

반응식

[CH3:1][O:2][C:3]1[C:11]([C:12](N)=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:15]=[CH:16]/[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[N:6][NH:7]2.[OH-:23].[Li+].Cl>>[CH3:1][O:2][C:3]1[C:11]([C:12]([OH:23])=[O:13])=[CH:10][CH:9]=[C:8]2[C:4]=1[C:5](/[CH:15]=[CH:16]/[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[N:6][NH:7]2

참가 물질

반응물 3

HCID 313Hydrochloric Acid

HCID 3939Lithium Hydroxide

HCID 59797368HCID 59797368, 화합물

생성물 1

HCID 59797049HCID 59797049, 화합물

반응 조건

온도: 110 °C

실험 절차

22 mg of 4-methoxy-3-(E)-styryl-1H-indazole-5-carboxylic acid amide was added to 3 mL of 4N lithium hydroxide aqueous solution, and stirred at 110° C. for 4 hours. After cooling on ice, the reaction solution was neutralized with 2N hydrochloric acid under ice cooling, and the precipitated crystals were collected by filtration and washed with water. This was then dried under reduced pressure, to afford 20 mg of the title compound as brown crude crystals.

후처리

temperatureAfter cooling on ice
filtrationthe precipitated crystals were collected by filtration
washwashed with water
customThis was then dried under reduced pressure

출처 및 근거

ORD 기록: ord-68273f5260b9449c8cffa603ab0d3dfb
출처 데이터셋: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07429609B2

반응 노트

불러오는 중…