Dimethylformamide → propargyl N-methoxy-2,4-dichlorobenzimidate

HRID 3405

반응식

HRID 3405 반응식
[CH3:1][O:2][NH:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:6]=1[Cl:12].C(=O)([O-])[O-].[K+].[K+].[CH2:20](Br)[C:21]#[CH:22].CN(C)C=O>O>[CH3:1][O:2][N:3]=[C:4]([O:13][CH2:22][C:21]#[CH:20])[C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:6]=1[Cl:12]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 7842Propargyl bromideHCID 11430Potassium CarbonateHCID 189350352,4-dichloro-N-methoxybenzamide

생성물 1

HCID 53654798propargyl N-methoxy-2,4-dichlorobenzimidate수율 29.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1.0 g of N-methoxy-2,4-dichlorobenzamide, 0.75 g of potassium carbonate and 0.65 g of propargyl bromide were added to 10 ml of N,N-dimethylformamide, and the mixture was stirred for 3 hours. After completion of the reaction, water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The extract was dried, concentrated and purified by silica gel column chromatography to obtain 0.35 g of propargyl N-methoxy-2,4-dichlorobenzimidate.

후처리

  1. additionwas added to the reaction solution
  2. extractionthe mixture was extracted with ethyl acetate
  3. customThe extract was dried
  4. concentrationconcentrated
  5. custompurified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-bc47ddbc82764811b755545cf676a4fc
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05733935

연결된 노트

불러오는 중…