Sodium Thiosulfate → HCID 178419485, 화합물

HRID 34083노트

반응식

HRID 34083 반응식
[NH:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[N:2]1.[Br:10]N1C(=O)CCC1=O.S([O-])([O-])(=O)=S.[Na+].[Na+]>CN(C)C=O.C(OCC)(=O)C>[Br:10][C:3]1[C:4]2[CH:5]=[N:6][CH:7]=[CH:8][C:9]=2[NH:1][N:2]=1

참가 물질

6

반응물 3

HCID 24477Sodium ThiosulfateHCID 67184N-bromobutanimideHCID 199305001H-Pyrazolo[4,3-c]pyridine

생성물 1

HCID 178419485HCID 178419485, 화합물수율 73.3%

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 3.85 g of 1H-pyrazolo[4,3-c]pyridine in 50 mL of N,N-dimethylformamide was added 6.04 g of N-bromosuccinimide at room temperature and stirred at this temperature for 2 hours. Adding 10 mL of 10% sodium thiosulfate aqueous solution, the solution was diluted with ethyl acetate. The organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated, to afford 4.69 g of the title compound as pale red-brown crystals.

후처리

  1. washThe organic layer was washed successively with saturated aqueous ammonium chloride and saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customthe solvent was evaporated

출처 및 근거

ORD 기록
ord-c33490b896594d5d9cb0c618ffaf0a57
출처 데이터셋
uspto-grants-2008_09
특허 번호
US07429609B2

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