Methyl iodide → 3-Iodo-4,5-dimethoxybenzaldehyde
반응식
[I:1][C:2]1[C:3]([OH:12])=[C:4]([O:10][CH3:11])[CH:5]=[C:6]([CH:9]=1)[CH:7]=[O:8].[C:13](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[CH3:11][O:10][C:4]1[CH:5]=[C:6]([CH:9]=[C:2]([I:1])[C:3]=1[O:12][CH3:13])[CH:7]=[O:8]참가 물질
5
실험 절차
A mixture of 5-iodovanillin (7 g, 25.18 mmole), potassium carbonate (8.78 g, 63.53 mmole) and iodomethane (6.43 g, 45.30 mmole) was suspended in 60 mL of DMF and stirred at room temperature for 14 hours. The reaction mixture was quenched with water and extracted with diethyl ether. The organic layer was dried over MgSO4, filtered and evaporated in vacuo to obtain a solid which was recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%).
후처리
- customThe reaction mixture was quenched with water
- extractionextracted with diethyl ether
- dry with materialThe organic layer was dried over MgSO4
- filtrationfiltered
- customevaporated in vacuo
- customto obtain a solid which
- customwas recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%)
출처 및 근거
- ORD 기록
- ord-cf2a47a2c6ac4469ba02a0f92452f246
- 출처 데이터셋
- uspto-grants-1999_01
- 특허 번호
- US05856323
반응 노트
불러오는 중…